About

Colorectal cancer is the 3^rd most common type of cancer worldwide and its occurrence is increasing, especially in populations with lower socioeconomic status, due to unhealthy dietary habits and lifestyle among others. The research project ‘ONCODIR: Evidence-based Participatory Decision Making for Cancer Prevention through implementation’ will identify risk factors associated with colorectal cancer and will integrate multidisciplinary research methods and technologies (including health policy analytics, artificial intelligence and decision support theories) to deliver evidence-based and personalised recommendations on colorectal cancer prevention.

ONCODIR is developing a platform based on artificial intelligence and privacy principles. It will provide recommendation services based on input from citizens, clinicians and policy-makers. We will consider factors such as lifestyle, nutrition and economics. To validate the ONCODIR results, we will conduct laboratory tests and pilots in five EU countries that will involve medical scientists, healthcare providers, foundations and consortium experts and will consider cost-effectiveness, affordability and cost-benefit parameters. The ONCODIR consortium consists of partners from diverse technological and scientific domains with a strong research capacity. ONCODIR is part of the Cancer Mission cluster of projects focused on prevention and early detection.”

IDENTIFY main correlations, barriers and significant factors of CRC

ENSURE equal an affordable access to cancer prevention strategies for everyone between and within EU countries

PROVIDE innovative AI-powered personalised prevention approaches

ENHANCE the ongoing evidence-based CRC prevention programmes for precise CRC primary prevention

ESTABLISH risk-based stratification for citizens considering structural and behavioural intervention through participatory approach

DESIGN intelligent monitoring tools for policy makers through a participatory co-designing approach

Duration

06/2023 to 11/2026

Programme

Horizon Europe

HORIZON-MISS-2021-CANCER-01

Research & Innovation Action

Reference

101104777

Structure

WP1: Project & Risk Management and Coordination

WP1 aims a) to effectively monitor the project, in administrative, technical, scientific, and financial terms; b) to guarantee the adherence of the work to the overall project plans, available resources, and timing; c) to assure and manage all the medical and clinical activities; d) to implement the Ethics and GDPR compliance procedures and relevant legislation; e) to assure the high quality of the project outcomes and compliance with emerging standards; f) to identify project risks by performing effective risk management; g) to define and update the project data management plan.

D1.1 Report on Project and Data Management version 1

D1.2 Report on Project and Data Management version 2

D1.3 DMP version 1

D1.4 DMP version 2

WP2: Participatory Implementation Research Framework and System Co-Design

WP2 aims a) to identify the end user’s needs and requirements and adapt the developed tools based on these b) to implement all Co-creation/design/development activities with the ONCODIR end users c) to identify the CRC prevalence factors within and between EU countries and regions based on retrospective data d) to identify the behavioural factors of wider populations in the EU that increase the risk of CRC e) to investigate and address the various factors that affect the implementation in real-life settings and help evidence-based policies creation.

D2.1 CRC Prevalence factors and barriers identification

D2.2 System co-design activities and implementation research version 1

D2.3 System co-design activities and implementation research version 2

D2.4 Policy brief formulating recommendations based on the research and innovation strand of the ‘Prevention and early detection’ annual cluster meeting version 1

D2.5 Policy brief formulating recommendations based on the research and innovation strand of the ‘Prevention and early detection’ annual cluster meeting version 2

D2.6 Policy brief formulating recommendations based on the research and innovation strand of the ‘Prevention and early detection’ annual cluster meeting version 3

D2.7 Policy brief formulating recommendations based on the research and innovation strand of the ‘Prevention and early detection’ annual cluster meeting version 4

D2.8 Citizen engagement summary report

D2.9 Report addressing inequalities recommendations

WP3: Co-creative Engagement, and Standardised and Trustworthy Data Flows

WP3 aims a) to ensure the collection of data from relevant data sources for modelling and algorithm development; b) to deploy a data collection framework for collecting, parsing, integrating and formatting heterogeneous data; c) to develop a co-creating and -designing platform addressed to the relevant stakeholders based on CI/CD through modular architecture; d) to use SotA techniques for privacy preserving data processing. e) to provide FAIR access to research data; f) to develop a customised and project oriented multi-omics data fusion engine; g) to develop Bias detection and trustworthy AI modules.

D3.1 ONCODIR Co-Creative Stakeholders’ Engagement, Trustworthness assessment, and Multi-omics data fusion. version 1

D3.2 ONCODIR Co-Creative Stakeholders’ Engagement, Trustworthness assessment, and Multi-omics data fusion. version 2

D3.3 ONCODIR Open Data Bank

WP4: Targeted & Intelligent Participatory Interventions for Cancer Prevention

WP4 aims a) to develop the ONCODIR tools along with the policy makers, patients/citizens and clinicians in a co-participatory approach b) to integrate ONCODIR’s tools in a – secure and standard compliant – by – design methodology.

D4.2 ONCODIR Integrated Intelligent Platform for Citizens, Clinicians & Policy Makers version 2

WP5: Financial, Clinical and Political Analyses for ONCODIR Adoption

WP5 aims a) to evaluate the ONCODIR prevention programmes with respect to their cost effectiveness, affordability and cost benefit, considering the standards of value based care and the respective health economics benchmarking methods b) to investigate cost balancing and demand generating financial schemes that will lead to increased CRC prevention both in private and public Healthcare settings, c) to underline behavioural factors that have significant impact on improved prevention strategies.

D5.1 ONCODIR cost and economic analysis version 1

D5.2 ONCODIR cost and economic analysis version 2

D5.3 ONCODIR Guidelines and uptake

WP6: Long-lasting Validation of ONCODIR Solutions and Methodologies and End-user upskilling

WP6 aims a) to provide detailed specifications of the test cases and set up the pilot sites; b) to implement, demonstrate and validate the six (6) ONCODIR pilots in six (6) EU countries; c) to provide training material to end users; d) to collect citizens’ and policymakers’ explicit feedback through interviews and questionnaires; e) to deliver overall evaluation results.

D6.1 ONCODIR demo activities, training and lessons learned version 1

D6.2 ONCODIR demo activities, training and lessons learned version 2

WP7: Synergistic Impact creation & Bottom-up Innovation

WP7 aims a) to develop and implement a comprehensive communication and dissemination strategy with measurable goals and sustained impact beyond the life of the project; b) to deliver high impact communication, engagement and dissemination activities to relevant audiences; c) to publish project’s results in dedicated high impact journals; d) to generate significant engagement with key stakeholders; e) to develop and implement a comprehensive exploitation strategy including a Roadmap to 2030 to prepare the market for ONCODIR’s key results.

D7.1 ONCODIR Dissemination, Communication, Exploitation and IPR Management version 1

D7.2 ONCODIR Dissemination, Communication, Exploitation and IPR Management version 2

D7.3 ONCODIR Dissemination, Communication, Exploitation and IPR Management version 3

D7.4 ONCODIR Living Lab Performance Evaluation

D7.5 Initial common work plan for scientific collaboration under the ‘Prevention and early detection’ cluster

D7.6 Conclusions of common annual meeting of the ‘Prevention and early detection’ cluster version 1

D7.7 Conclusions of common annual meeting of the ‘Prevention and early detection’ cluster version 2

D7.8 Conclusions of common annual meeting of the ‘Prevention and early detection’ cluster version 3

D7.9 Conclusions of common annual meeting of the ‘Prevention and early detection’ cluster version 4

D7.10 ‘Prevention and early detection’ cluster Common video and brochure

Deliverables

D1.1 Report on Project and Data Management version 1

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D1.2 Report on Project and Data Management version 2

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D1.3 DMP version 1

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D1.4 DMP version 2

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D2.1 CRC Prevalence factors and barriers identification

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D2.2 System co-design activities and implementation research version 1

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D2.3 System co-design activities and implementation research version 2

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D2.4 Policy brief formulating recommendations based on the research and innovation strand of the ‘Prevention and early detection’ annual cluster meeting version 1

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D2.5 Policy brief formulating recommendations based on the research and innovation strand of the ‘Prevention and early detection’ annual cluster meeting version 2

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D2.6 Policy brief formulating recommendations based on the research and innovation strand of the ‘Prevention and early detection’ annual cluster meeting version 3

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D2.7 Policy brief formulating recommendations based on the research and innovation strand of the ‘Prevention and early detection’ annual cluster meeting version 4

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D2.8 Citizen engagement summary report

Download

D2.9 Report addressing inequalities recommendations

Download

D3.1 ONCODIR Co-Creative Stakeholders’ Engagement, Trustworthness assessment, and Multi-omics data fusion. version 1

Download

D3.2 ONCODIR Co-Creative Stakeholders’ Engagement, Trustworthness assessment, and Multi-omics data fusion. version 2

Download

D4.2 ONCODIR Integrated Intelligent Platform for Citizens, Clinicians & Policy Makers version 2

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D5.1 ONCODIR cost and economic analysis version 1

Download

D5.2 ONCODIR cost and economic analysis version 2

Download

D5.3 ONCODIR Guidelines and uptake

Download

D6.1 ONCODIR demo activities, training and lessons learned version 1

Download

D6.2 ONCODIR demo activities, training and lessons learned version 2

Download

D7.1 ONCODIR Dissemination, Communication, Exploitation and IPR Management version 1

Download

D7.2 ONCODIR Dissemination, Communication, Exploitation and IPR Management version 2

Download

D7.3 ONCODIR Dissemination, Communication, Exploitation and IPR Management version 3

Download

D7.4 ONCODIR Living Lab Performance Evaluation

Download

D7.5 Initial common work plan for scientific collaboration under the ‘Prevention and early detection’ cluster

Download

D7.6 Conclusions of common annual meeting of the ‘Prevention and early detection’ cluster version 1

Download

D7.7 Conclusions of common annual meeting of the ‘Prevention and early detection’ cluster version 2

Download

D7.8 Conclusions of common annual meeting of the ‘Prevention and early detection’ cluster version 3

Download

D7.9 Conclusions of common annual meeting of the ‘Prevention and early detection’ cluster version 4

Download

D7.10 ‘Prevention and early detection’ cluster Common video and brochure

Download

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